Formulation And Development Of Enz-1-Targeted Therapy Using Benzimidazole And Benzotriazole Derivatives For Leukemia Treatment: A Comprehensive Study Including Benzene Sulfonamide Derivatives For Antifungal Applications

Author

Ahmed Ashraf Anwar Elsyyad, Prairie View A&M University

Date of Award

8-2025

Document Type

Thesis

Degree Name

Master of Science

Degree Discipline

Chemistry

Abstract

This thesis highlights two chemistry-centered projects that demonstrate the pivotal role of synthetic organic methodologies in addressing critical health concerns. The first project involved the multi-step synthesis of benzimidazole and benzotriazole derivatives from aniline substrates, achieving high yields of 80–90%. These compounds were rigorously characterized by 1H and 13C NMR spectroscopy, establishing their structural integrity and laying the groundwork for future evaluations against leukemia. The second project involved designing small-molecule inhibitors to combat antifungal resistance, based on a piperazine scaffold, targeting Sec14 lipid-binding proteins essential for fungal viability. The synthesized (phenylsulfonyl) piperazine derivatives also displayed excellent yields and were thoroughly characterized.

Keywords: cancer, leukemia, aniline, benzimidazole, benzene triazoles, sulfonyl chloride, antifungal, NMR

Committee Chair/Advisor

Sameh Abdelwahed

Committee Member

Ananda Amarasekara

Committee Member

Harshica Fernando

Publisher

Prairie View A&M University

Rights

Date of Digitization

8/06/2025

Contributing Institution

J. B . Coleman Library

City of Publication

Prairie View

MIME Type

Application/PDF

Recommended Citation

Anwar Elsyyad, A. A. (2025). Formulation And Development Of Enz-1-Targeted Therapy Using Benzimidazole And Benzotriazole Derivatives For Leukemia Treatment: A Comprehensive Study Including Benzene Sulfonamide Derivatives For Antifungal Applications. Retrieved from https://digitalcommons.pvamu.edu/pvamu-theses/1552