"Building BLOCK strategies for the synthesis of molecular clefts with i" by Ronald N. Warrener, Davor Margetic et al.
 

Title

Building BLOCK strategies for the synthesis of molecular clefts with inside functionality

Document Type

Article

Publication Date

7-29-1999

Abstract

(equation presented) A new general route to U-type cavity structures (molecular clefts) with inside functionality has been developed using wall extension or base/ roof assembly methods which draw upon (i) the 1,3-dipolar cycloaddition reaction between alkenes and cyclobutene epoxides (ACE coupling) or (ii) the Diels Alder reaction of alkenes with fused dihydropyridazines (s-tetrazine coupling). In this way, functional units (e.g., crown ethers, redox-active naphthalenes) have been attached stereospecifically to short-walled bis-alkenes 1-5 to produce cavity structure 6-10 with top-of-wall separations (C to C) from 4.5 to 12.7 Å.

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