Title

Lectin receptors for endometrial H-type 1 antigen on goat conceptuses

Document Type

Article

Publication Title

American Journal of Reproductive Immunology

Abstract

Problem: The goal of this study was to determine if caprine conceptuses express lectin-like receptors for endometrial H-type 1 (HT1) antigen. Method of Study: Conceptus tissues were collected during the apposition, adhesion and attachment phases of placentation and evaluated using immunofluorescence microscopy. Results: Conceptus staining for the trisaccharide lacto-N-fucopentaose-1 was strong and uniform during apposition of fetal and maternal tissues but changed by day 25 of pregnancy when large aggregates of intense staining were observed. Monoclonal antibodies to galectin-3 did not stain conceptus tissue during the apposition phase but intense punctate staining was observed after day 25. Strong uniform staining for Lewis Y antigen was detected only on day 17 of pregnancy. Conclusion: Conceptus tissue expresses potential receptors for endometrial HT1 antigen. Carbohydrate-lectin interactions may facilitate attachment of the apical surfaces of uterine epithelial cells and trophectoderm during the early stages of placentation. © Blackwell Munksgaard, 2004.

First Page

74

Last Page

80

DOI

10.1111/j.1600-0897.2004.00190.x

Publication Date

1-1-2004

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