Essential role of endogenously synthesized tylosin for induction of ermSF in Streptomyces fradiae

Document Type

Article

Publication Title

Antimicrobial Agents and Chemotherapy

Abstract

We compared ermSF induction in wild-type Streptomyces fradiae NRRL B- 2702 and that in GS-14, a tylA mutant which cannot synthesize tylosin. Our findings suggest that (i) endogenously synthesized tylosin plays an obligatory role in ermSF induction and (ii) tylosin, or a biosynthetic intermediate beyond tylactone, has an 'autocrine' function that induces ErmSF synthesis, thereby enabling S. fradiae to resist higher levels of tylosin.

First Page

1203

Last Page

1205

DOI

10.1128/aac.41.5.1203

Publication Date

1-1-1997

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