Title
Delivering value from sperm proteomics for fertility
Document Type
Article
Publication Title
Cell and Tissue Research
Abstract
Fertilization of an egg by a spermatozoon sets the stage for mammalian development. Viable sperm are a prerequisite for successful fertilization and beyond. Spermatozoa have a unique cell structure where haploid genomic DNA is located in a tiny cytoplasmic space in the head, mitochondria in the midpiece and then the tail, all enclosed by several layers of membrane. Proteins in sperm play vital roles in motility, capacitation, fertilization, egg activation and embryo development. Molecular defects in these proteins are associated with low fertility or in some cases, infertility. This review will first summarize genesis, molecular anatomy and physiology of spermatozoa, fertilization, embryogenesis and then those proteins playing important roles in various aspects of sperm physiology. © Springer-Verlag 2012.
First Page
783
Last Page
793
DOI
10.1007/s00441-012-1452-2
Publication Date
9-1-2012
Recommended Citation
Govindaraju, A., Dogan, S., Rodriguez-Osorio, N., Grant, K., Kaya, A., & Memili, E. (2012). Delivering value from sperm proteomics for fertility. Cell and Tissue Research, 349 (3), 783-793. https://doi.org/10.1007/s00441-012-1452-2