Two new triterpene glycosides from centella asiatica
Abstract
Phytochemical investigation of the leaves of Centella asiatica resulted in the isolation and characterization of eight triterpenes and/or saponins [which were characterized as 23-O-acetylmadecassoside (1), asiatic acid (2), madecassic acid (3), asiaticoside C (4), asiaticoside F (5), asiaticoside (6), madecassoside (7), and 23-O-acetylasiaticoside B (8)] together with sitosterol 3-O-β-glucoside (9), stigmasterol 3-Oβ-glucoside (10), and querectin-3-O-β-D-glucuronide (11). A new ursane-derived saponin (23-O-acetylmadecassoside) and a new oleanane-derived saponin (23-O-acetylasiaticoside B) were found as well. Structure elucidation was done by using spectroscopic techniques (HRESIMS, 1D and 2DNMR), chemical methods, and comparative literature studies. © Georg Thieme Verlag KG Stuttgart - New York.