Title
Hydroxyapatite grafted carbon nanotubes and graphene nanosheets: Promising bone implant materials
Document Type
Article
Publication Title
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Abstract
In the present study, hydroxyapatite (HA) was successfully grafted to carboxylated carbon nanotubes (CNTs) and graphene nanosheets. The HA grafted CNTs and HA-graphene nanosheets were characterized using FT-IR, TGA, SEM and X-ray diffraction. The HA grafted CNTs and graphene nanosheets (CNTs-HA and Gr-HA) were further used to examine the proliferation and differentiation rate of temperature-sensitive human fetal osteoblastic cell line (hFOB 1.19). Total protein assays and western blot analysis of osteocalcin expression were used as indicators of cell proliferation and differentiation. Results indicated that hFOB 1.19 cells proliferate and differentiate well in treatment media containing CNTs-HA and graphene-HA. Both CNTs-HA and graphene-HA could be promising nanomaterials for use as scaffolds in bone tissue engineering. © 2014 Elsevier B.V. All rights reserved.
First Page
410
Last Page
416
DOI
10.1016/j.saa.2014.04.004
Publication Date
11-11-2014
Recommended Citation
Oyefusi, A., Olanipekun, O., Neelgund, G., Peterson, D., Stone, J., Williams, E., Carson, L., Regisford, G., & Oki, A. (2014). Hydroxyapatite grafted carbon nanotubes and graphene nanosheets: Promising bone implant materials. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 132, 410-416. https://doi.org/10.1016/j.saa.2014.04.004