Natural-synthetic polymer blend composite scaffold for bone tissue engineering: Study of in vitro degradation and protein adsorption

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Conference Proceeding

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In the current study, poly(hydroxy butyrate-co-hydroxy-valerate) (PHBV) was blended with a synthetic polymer poly (L-lactic acid) (PLLA), to control the degradation rate and process of composite scaffolds, as PLLA has a much higher degradation rate than PHBV. PHBV/PLLA blends were used as polymer matrices for composite scaffolds. Emulsion freezing/freeze-drying technique was used to fabricate composite scaffolds based on these blends and containing nano-sized hydroxyapatite (nHA). In vitro degradation tests of composite scaffolds were conducted by immersing samples in phosphate buffered saline (PBS) for various periods of time. It was found that the composition of polymer blends affected water uptake of scaffolds. Composite scaffolds exhibited enhanced adsorption of bovine serum albumin (BSA), a model protein. © (2014) Trans Tech Publications, Switzerland.

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