Chitosan coated and non-coated composite scaffolds based on poly (Caprolactone) (PCL) and hydroxyapatite (HA)

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Tissue engineering (TE) scaffold is an artificial structure that is implanted in our body on which tissue grows to solve the problem of a missing or damaged organ. A wide range of biomaterials can be used to produce the TE scaffolds. This study reports the comparison of chitosan coated and uncoated three-dimensional composite scaffolds composed of Hydroxyapatite (HA) and polycaprolactone (PCL)) via thermally induced phase separation (TIPS) and freeze-drying method. Three types of the scaffolds, namely, PCL and PCL/HA were coated with hydrophilic chitosan polymer. Characteristics such as wettability, morphological structure and water uptake in coated and non-coated scaffolds were studied and compared using a contact angle, a Scanning Electron Microscopy (SEM), an Energy Dispersive X-Ray (EDX). The composite scaffolds were porous and had interconnected pore structures. The ranges of pores were different from several microns to a few hundred microns. The coated layer improved the wettability of composite scaffolds. These results shows that the chitosan coated composite scaffolds were more favourable for TE application than their uncoated counterparts.

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