Title
Identification of the product of toxoflavin lyase: Degradation via a baeyer-villiger oxidation
Document Type
Article
Publication Date
3-21-2012
Abstract
Toxoflavin (an azapteridine) is degraded to a single product by toxoflavin lyase (TflA) in a reaction dependent on reductant, Mn(II), and oxygen. The isolated product was fully characterized by NMR and MS and was identified as a triazine in which the pyrimidine ring was oxidatively degraded. A mechanism for toxoflavin degradation based on the identification of the enzymatic product and the recently determined crystal structure of toxoflavin lyase is proposed. © 2012 American Chemical Society.
Recommended Citation
Philmus, B., Abdelwahed, S., Williams, H., Fenwick, M., Ealick, S., & Begley, T. (2012). Identification of the product of toxoflavin lyase: Degradation via a baeyer-villiger oxidation. Retrieved from https://digitalcommons.pvamu.edu/chemistry-physics-facpubs/16