Intramolecular Azide-Olefin Cycloadditions. A Novel Synthesis of 2,5-Dihydrooxazoles
A facile synthetic route from aldehydes to allyl α-azidoalkyl ether 2 is described. Thermolysis of 2 proceeds by intramolecular azide-olefin cycloaddition via triazolines and provides a novel synthesis of 2,5-dihydrooxazoles 6. The use of silica gel in the chemoselective conversion of the intermediate triazolines to bicyclic aziridines 7 is described. © 1988, American Chemical Society. All rights reserved.
Hassner, A., Amarasekara, A., & Andisik, D. (1988). Intramolecular Azide-Olefin Cycloadditions. A Novel Synthesis of 2,5-Dihydrooxazoles. Retrieved from https://digitalcommons.pvamu.edu/chemistry-physics-facpubs/130