Lectin receptors for endometrial H-type 1 antigen on goat conceptuses
American Journal of Reproductive Immunology
Problem: The goal of this study was to determine if caprine conceptuses express lectin-like receptors for endometrial H-type 1 (HT1) antigen. Method of Study: Conceptus tissues were collected during the apposition, adhesion and attachment phases of placentation and evaluated using immunofluorescence microscopy. Results: Conceptus staining for the trisaccharide lacto-N-fucopentaose-1 was strong and uniform during apposition of fetal and maternal tissues but changed by day 25 of pregnancy when large aggregates of intense staining were observed. Monoclonal antibodies to galectin-3 did not stain conceptus tissue during the apposition phase but intense punctate staining was observed after day 25. Strong uniform staining for Lewis Y antigen was detected only on day 17 of pregnancy. Conclusion: Conceptus tissue expresses potential receptors for endometrial HT1 antigen. Carbohydrate-lectin interactions may facilitate attachment of the apical surfaces of uterine epithelial cells and trophectoderm during the early stages of placentation. © Blackwell Munksgaard, 2004.
Woldesenbet, S., Garcia, R., Igbo, N., Leake, J., Lewis, S., & Newton, G. (2004). Lectin receptors for endometrial H-type 1 antigen on goat conceptuses. American Journal of Reproductive Immunology, 52 (1), 74-80. https://doi.org/10.1111/j.1600-0897.2004.00190.x