Applications of Metabolomics in Reproductive Biology
Animal Models and Human Reproduction
Metabolomics can be performed associated with other omics approaches such as genomics, transcriptomics, and proteomics. For example, a recent study showed interesting results using an Integrative Personal Omics Profile (iPOP) to identify markers for possible diseases affecting an individual. This chapter suggests that such a method leads to an early diagnosis and facilitates prevention of certain diseases, such as type 2 diabetes, aplastic anemia, human rhinovirus infection, and respiratory syncytial virus infection. For assisted reproductive technologies (ART), metabolomics methods have been chosen as noninvasive approaches to improve the assessment of embryo quality. Metabolic profiling analysis of follicular fluids (FF) from lactating cows and heifers by gas chromatography-mass spectrometry (GC-MS) identified the presence of greater concentrations of saturated fatty acids in follicles from cows than those from heifers. Large animals have been used as models for research of human disease and physiology due to their specific physiological characteristics, sometimes similar to the human.
Cazaux Velho, A., Oliveira, R., Dinh, T., Moura, A., Kaya, A., & Memili, E. (2017). Applications of Metabolomics in Reproductive Biology. Animal Models and Human Reproduction, 509-518. https://doi.org/10.1002/9781118881286.ch20