Title
Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis
Document Type
Article
Publication Title
Journal of Biological Chemistry
Abstract
Background: Therapeutic values of Valeriana officinalis have been associated with sesquiterpenes whose biosynthetic origins have remained enigmatic. Results: A cyclobutenyl intermediate in the catalytic cascade of valerena-1,10-diene synthase is reported. Conclusion: A new class of sesquiterpene synthases for the biosynthesis of sesquiterpenes harboring isobutenyl functional groups is proposed. Significance: Similar catalytic mechanisms from evolutionarily diverse organisms are proposed and portend sources for sesquiterpene diversity. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
First Page
3163
Last Page
3173
DOI
10.1074/jbc.M112.415836
Publication Date
2-1-2013
Recommended Citation
Yeo, Y., Nybo, S., Chittiboyina, A., Weerasooriya, A., Wang, Y., Góngora-Castillo, E., Vaillancourt, B., Buell, C., Dellapenna, D., Celiz, M., Daniel Jones, A., Wurtele, E., Ransom, N., Dudareva, N., Shaaban, K., Tibrewal, N., Chandra, S., Smillie, T., Khan, I., Coates, R., Watt, D., & Chappell, J. (2013). Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis. Journal of Biological Chemistry, 288 (5), 3163-3173. https://doi.org/10.1074/jbc.M112.415836